Steroid Use in Cats: Is it Dangerous?

Nov 11, 2012 by     38 Comments    Posted under: Tips & Advice

Ms. Worry set up a consultation with me, Dr. Catz, to discuss the use of Prednisolone in her cat, Hershey Squirts.  My manager, Ms. E. Calm held the phone far away from her ear as Ms. Worry screamed that she thought the prescription from Dr. Catz for steroids would shorten Squirts’ life. Ms. Worry said her mother’s face had become permanently bloated and she had terrible mood swings when she was prescribed steroids for her asthma.

What are steroids?

Steroids are natural substances produced by the adrenal glands.

Corticosteroids are the type used for therapy in cats. Anabolic (performance-enhancing) steroids are not used in feline practice.

There are also synthetic steroids that are used to treat a variety of feline diseases.  The most common steroids used in feline medicine are prednisolone, dexamethasone, triamcinolone and budesonide.  Methylprednisolone is a slow release “repositol” steroid that is largely no longer used in cats since the risk is much greater for potential adverse effects than with thee shorter acting oral steroids.  Once given, a long acting injection can’t be reversed.

Steroids have potent anti-inflammatory and anti-allergic effects.

Some of the allergic conditions treated successfully with steroids in cats:

  • Allergic reactions to environmental stimuli, either by contact or inhalation
  • Flea allergic dermatitis
  • Allergic bronchitis
  • Allergic reactions to bee stings or spider bites

Inflammation causing acute or chronic pain can be treated with steroids:

  • Osteoarthritis
  • Trauma, especially to the head
  • Disc problems
  • Soft tissue injuries like sprains or strains
  • Gingivitis

Prednisolone is often used in combination with other drugs for cancer treatment in cats.

Steroids may be used to stop the process of immune-destruction by slightly reducing an overactive immune response.

Some of the diseases in this category are:

  • Stomatitis (inflammation in the mouth)
  • Pemphigus (skin disease affecting ears, nose and anus)
  • Autoimmune hemolytic anemia
  • Certain kidney diseases

Corticosteroids are not “strong” medicines and are commonly used very effectively in treating many disorders in feline medicine, ranging from minor to life-threatening problems.

Most of the time, relatively high doses are used initially to achieve an effect, then tapered to the lowest dose and frequency needed to keep clinical signs at bay. Tapering allows the body to adapt to having the steroids removed from the body. Sometimes steroids can be stopped entirely at the end of the taper and other times are they are required long term. Some are started up as needed on a “pulse” or temporary basis when a disease “flares up”

Fortunately, cats are extremely resistant to the side effects of steroids.

The annoying side effects that dogs may experience rarely if ever occur in cats unless a profound overdose of steroids are prescribed.  The common side effects in dogs are increased hunger, thirst and urination, panting, pot-bellied appearance, lethargy,  and thinning of the skin.

Adverse effects of steroids in cats are relatively uncommon and almost always reversible.

The most common potential adverse effect of steroids in cats is diabetes mellitus.  This usually only occurs in cats that are already predisposed to diabetes, especially in those who are obese and/or on high carbohydrate diets. A feline doctor will require a baseline blood glucose level prior to starting corticosteroids and will monitor blood glucose levels periodically as long as the drug is continued.  The interval between glucose tests is dependent on the risks in a given patient as well as the dose required to control disease in that cat. If diabetes does show up secondary to steroid use, it will almost always go away after the drug is tapered and discontinued.   Some steroids have less systemic (whole body) side effects, notably budesonide when compared to the more commonly used prednisolone, and can still be used safely in some patients who have become diabetic while on prednisolone.  Also, steroid inhalers used for allergic bronchitis (Feline Asthma) have fewer systemic effects than oral steroids.

A less common side effect of corticosteroid use is to uncover hidden congestive heart failure (CHF).   If heart disease is undetected (occult), especially if a heart murmur is not heard, fluid can rapidly fill up the lungs causing labored breathing and distress after a steroid injection is given. If the patient is promptly seen by a vet on an emergency basis and CHF is diagnosed by a chest x-ray, oxygen therapy and diuretic injections generally cause the fluid to be urinated out and an echocardiogram can be performed to further define the heart condition.

One additional potential adverse effect is infection due to immunosuppression if high doses of steroids are needed to control an overactive/destructive immune response (diseases described earlier).  Infections may develop due to less than optimal immunity. Frequently these are upper respiratory infections (cold symptoms).  The combination of tapering and discontinuing use of the steroid and adding in antibiotics generally lead to resolution of the infection without complications.

Ms. Calm directed Ms. Worry to read this blog entry prior to her consult with Dr. Catz.  Ms. Worry reluctantly started prednisolone daily for 14 days and Squirt’s diarrhea resolved.  At his two week recheck, Dr. Catz began to taper the dose and frequency of  Squirt’s medication and explained that half the original dose given every 48 to 72 hours is likely to be well tolerated without serious side effects for the rest of Squirt’s life.

Dr Elyse Kent

Dr. Elyse Kent graduated from Michigan State University College of Veterinary Medicine in 1980 and completed an Internship at West Los Angeles Veterinary Medical Group in 1981.

In her early years in practice, Dr. Kent began to see a need for a separate medical facility just for cats, where fear and stress would be reduced for feline patients. In 1985, in a former home in Santa Monica, Dr. Kent opened the only exclusively feline veterinary clinic in Los Angeles, Westside Hospital for Cats (WHFC). Along with other forward-thinking feline practitioners from across North America, Dr. Kent founded the Academy of Feline Medicine in 1991. Through the efforts of these practitioners, feline medicine and surgery became a certifiable species specialty through the American Board of Veterinary Practitioners (ABVP). Dr. Kent became board certified in Feline Practice in the first group to sit for the Feline exam in 1995. She certified for an additional ten (10) years in 2005. There are now 78 feline specialists in the world. Dr. Kent served as the Feline Regent and Officer on the Council of Regents for 9 years. She is currently the immediate Past President of the ABVP, which certifies all species specialists. She also heads up a task force joining certain efforts of the ABVP with The American Animal Hospital Association (AAHA). She currently serves as a Director on the Executive Board of The American Association of Feline Practitioners.

The present day WHFC facility opened in 2000. It was the fulfillment of a vision for a spacious, delightful, state of the art, full service cat medical center that Dr. Kent had dreamed of and planned for over many years.

Westside Hospital for Cats
2317 Cotner Ave.
Los Angeles, CA 90064

Phone: 310-479-2428

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  • I agree Dr. Kent. We treat inflammatory machines for a living, you gotta have steroids! Thanks for the perspective

  • Informative article. Thank you. And the photo at the top made me laugh out loud!

  • Informative article. Thank you. And the photo at the top made me laugh out loud!

    • jlung

      Hi Melanie, thanks for the feedback! Feel free to suggest any topics you would like one of the doctors to blog about,

    • jlung

      Hi Melanie, thanks for the feedback! Feel free to suggest any topics you would like one of the doctors to blog about,

  • Marcia

    Is that a Pallas cat in the pic?

    • jlung

      It is not but it sure does look like one now that you mention it.

  • Jo

    Good article. Goes a long way towards calming the fears of cat owners.

    Do you still advocate low dose prednisolone use for feline osteoarthritis in elderly cats with concurrent CKD? If so, what is your typical starting dose for these cats?

  • Jo

    Asking again as there has been no response: Is low dose prednisolone relatively safe to give a geriatric cat with chronic kidney disease (and hyperthyroidism) to treat inflammation and pain from arthritis? Yes, we have tried pain meds such as tramadol, gabapentin and buprenorphine, but none of them seem to be helping him much. That is why I am considering asking my vet for a low dose–maybe every other day administration–regimen of prednisolone. Could REALLY use felinedocs’ input on this! Please help!

    • Windingdown

      Hi Jo Low Dose Naltrexone (LDN) a tiny dose once a day for a cat works just like acupuncture dose it releases endorphins and its in a transdermal base for the ear once a day and helps inflammation google it.. best of luck.

      • Lola

        Thanks atiny dose. I wonder if Pred. Caused her kidney disease. – my cat ! She has been on pred for years! I tried to lower it to what the tech said and she went into shock in a week. I’m lowering the Pred chews slow now. She was put on for IBD . Hope her symtoms dont come back . But is too hard on kidneys.

        • Lola

          Now her winter asthma has come back and I have to raise the prednisilone again.

  • Marcus Brown Dvm


    Sorry for the delayed response. Tramadol does not seem to work for cats and they HATE the taste.

    Gabapentin and buprenorphine are very safe and effective medications. Sorry to hear that they are not helping. You may want to ask about Adequan inject-able.
    There are diets that are rich in Omega 3’s and chondrotin. Hills /d or Royal Canin Joint. You may want to pursue non-medical approaches such as acupuncture

    or laser therapy.

    I am including links from my clinic. You should consult with your veterinarian for therapies they would consider viable.

    My apologizes for the delay in response.

    • Windingdown

      BCP VET pharmacy in Texas has transdermal Tramadol. Works well with LDN since opiates cant be used with LDN..

    • Windingdown

      Also Low Dose Naltrexone (LDN) a tiny dose once a day for a cat works just like acupuncture dose it releases endorphins and its in a transdermal base for the ear once a day

  • Digby Joseph

    Hi – I’m currently weaning my kitty, Digby Joseph, off oral prednisone while at the same time introducing inhaled steroids for his asthma. He’s a chunky monkey weighing in at almost 20lbs. Will he begin losing weight once the oral steroids have been discontinued?

  • msdds1

    My cat was on low dose steroids for years. He had irritable bowl syndrom which I diagnosed. Dentist by profession. He lived to 18.5 years as an indoor/outdoor cat.

  • msdds1

    PS. my cat weight was 25 pounds on prednison. He gained five and than he stabilized at that weight. He was a happy cat. Bubba the bruiser.

  • Windingdown

    Check out Low Dose Naltrexone (LDN) it is now used on Cats with success.. it helps IBD big time! and CHEAP!!! Im using in stead of steroids on my cat who heart diease for possible cancer. I get mine for my kitty 2 mo supply of transdermal LDN 30.00 plus shipping.. I put on the ear ONCE a morning and that’s it.. works by reducing inflammation but its not a steroid, its an immune modulator so no messing up the immune system.. I get my kitties LDN from Skips Compounding on FL

  • Jo

    Windingdown, thank you so much for the info on LDN! Will do some research on that and talk to my vet about it, too. Have tried several months of Adequan, 8 acupuncture treatments, four laser treatments, Cosequin, Omega 3 oil, tramadol oral then transdermal, buprenorphine, gabapentin (did not do normal dose as was afraid it would negatively affect kidneys), deer antler velvet, various glucosamine/chondroitan treats, and I’m sure some other things I can’t think of right now. Feline arthritis sucks!

  • Jo

    Oh, the only thing that has helped Lucky’s arthritis a bit is a product called Hyaflex for Cats–liquid hyaluronic acid. I don’t understand why the oral version of HA would work when several months of Adequan injections, dosed as instructed by the maker, did not.

  • Ruth Santana

    My cat Sammy has a very painful inflammatory gum condition called stomatitis. I’ve read that low dose LDN could help him. He also has an anxiety disorder and very picky with food due to the pain in his mouth. I thought transdermal LDN would be ideal for him but I have not been able to find a place to buy it. I read some of you have been using this product. Could you please let me know how to obtain it. Thanks in advance

    • kamwick

      Ruth, please contact a feline dental specialist ASAP. The treatment of choice for chronic stomatitis in cats nowadays is full mouth extraction of all teeth and their roots (they need to take full dental X-rays before and after to make sure they remove everything). This resolves the problem in 60-80% of cats, as it seems to take away the main cause of the body’s inflammatory response. If not, the problem is generally much reduced and can be managed medically (this is happening with our cat so we are trying immunosuppressive doses of prednisolone, with the plan to taper it off over time, hopefully permanently. If this doesn’t do the trick we will try cyclosporine).

      I am so sorry to tell you this, but without removing his teeth, Sammys stomatitis will likely end up as a long slog downhill, and terribly reduce his quality of life. The steroids don’t do such a good job after a while. It is expensive, but most vets offer credit plans. Just make sure it’s a dental specialist with experience in this area.

      Best of luck to you and Sammy.

  • jgrif96229

    Our 12 year old silver r taby with painted tail was diagnosed with Nasal Lymphoma. His name is Leo. We are expats living in Singapore. There are lots of vets here but only about two facilities which treat things other than the typical routine shots and antibiotics.

    He was diagnosed in late July 2015. It is now October 20th. The first option offered by the clinic was a 12 month plan with weekly visits for Chemo and or radiation at a cost of $26,000 SD or about $19,000 USD. It will go into remission for awhile but it almost always come back. You repeat the process over again.

    Leo gets very stressed and drools but cooperates for vet visits. He would not handle that many visits. The other choice offered was to start him on prednissolone daily. We started down that road.

    Leo is a very hard cat to pill as his jaws are very strong and he really clamps down. We started pocketing the pills. That worked for about two weeks. Then we started grinding and placing in food. That worked for about two weeks. Then he started to ignore the foods we had used to pill even if they did not contain a pill. At that point we had no choice but to pill feed him. The solution that worked is to insert the pill where he is missing some teeth and let him swallow it.

    Upon going back to the vet for another problem he had gained almost two pounds. That other problem is what is contributing to the situation both physical and mentally for Leo.

    His pupil in one eye has now rotated back into his socket so you are seeing mostly white. The vet determined that he can still see out of the eye. He suggested not removing the eye as it will give an easy way for the turmor to grow. In other words the turmor has resistance with the eye. We did take home a gel type medication which I think it called Solonca from Sweden to keep his eye moistened.

    Leo seems to be depressed over this turn of events. He is still doing his usual things and then sleeping alot. The problem now is he is hiiding everywhere and coming out after we leave for work. Upon return he is out and we pill him. He eats and then hides out under the bed. Once we are alseep he comes up and snuggles for the whole night. Once we get up he finds a place to avoid pilling.

    The key to comfort for the remainer of his time with us is the consistant administration of meds. He is on a very reasonable dose and only feels off when he refuses to be pilled.

    We have a second 18 year old cat that takes a pill twice a day for over active thyroid. That cat is doing exceptionally well and we have been pilling him for about 4 years. Leo has seen Winston be pilled time after time so it is not like it is a new thing for him to see. Leo’s sense is THAT IS FINE FOR WINSTON BUT NOT FOR ME.

    I have compared treatment costs with USA contacts and friends and we are about the same costs here as in the USA. Cancer treatments in animals is very expensive. I would have opted but his kind of lymphoma has a high reocurrance rate.

    We chose QUALITY OF LIFE over stressing him out over 12 months of shots and weekly visits only to repeat it again 7 months down the road. It seems the cancer always wins.

    I know this is alot of text to read but I am hoping someone out there can shed some advise. I know you all feel my pain. I also know Leo might be with us only a couple of months more. I also know we have given Leo the best we could of everything. NOW IT IS UP TO US TO MAKE HIM COMFORTABLE.

    What are my options for a cat that is a strong hard to pill feline? Is there a long acting shot that could be used? What about the eye? Some days it has a slight pink as we think the eye is dryer now that it is more exposed. I asked the vet if he thought the eye would be forced out of the socket. His reply was that it would be at least 4 months from Octboer if and when that happend. Meanwhile other things will happen way before that. If it does move out of the socket than it might be time to remove the eye. He also felt he did not want to debulk the tumor as it will travel through his system and may hasten the lymphoma.

    His blood cell count is very good. The roof of his mouth is fine. The vet was very happy with where he was 90 days out from diagnosis.

    We have made and kept every appointment. The vet has checked all other vital signs and everything looks good.

    The options of places to treat this was only two here in Singapore. Places that could do all the testing and are well versed on this.

    I AM HOPING THAT SOMEWHERE ON THE ONLINE COMMUNITY MIGHT HAVE SOME MORE INSIGHT THAN WE HAVE IN MAKING LEO COMFORTABLE. The easiest solution is to suggest that we put him down. My only thought with that is his vitals are still very good and his interaction is fine. Right now Leo is annoyed, frustated and a little despondent. He stil has fight in him. At some point he will not and then it will be time to send him to the rainbow bridge. If he has not given up we will move forward.

    Yes we have decided to creamate Leo when his time has come. The will not be October 22nd though. Not till …..

    For those who may not have an idea or expertise but know someone who does, please pass this along. Thanks Joe and Anthony

    • Jodie Frayne

      They do have steroid shots that would have to be given once a month. My cat had one and it worked but now we are going to try pills

    • Maria

      Try to find a Holistic Vet. Go with natural treatments. I am so sorry for your kitty.

    • Rosa Sollecito

      HI, My cat Simba, a bengal, was recently diagnosed with large cell lymphoma. He will be 16 in August. I don’t have any insight for you but, it helped me to read your story. I’m afraid to give him the steroid medication as I’m afraid it will harm him further but, I guess that’s just my own fears? Seems, it will help him, as you said, to keep him comfortable and give him quality of life. Any reassurances from anyone is welcome. Rosa

  • jgrif96229

    sent the posting t below along with some pictures to the facebook message section.

  • Lola

    So expensive to take care of a sick pet. If I had money my cat would get it for sure!

  • Stacey Miller

    My cat has been sick since June. Thousands of $$$. Different diagnosis every time. It started with drooling & dehydration. Steroid shot & antibiotic, he seemed ok.
    September – drooling & dehydration, more severe this time. Blood tests normal. Diagnosed with herpes. Lysine recommended.
    October – Next came a UTI out of nowhere. Antibiotic cured that.
    12 days ago – Severe drooling & dehydration. X-Ray showed slight inflammation & constipation. Chest rattle. Diagnosed with bronchitis.
    2 days ago – Antibiotic not finished. Another X-Ray. Drooling again, chest rattle worse. Diagnosed with Feline Asthma. Now he’s on antibiotic, prednisone, & bronchial dilator. Trembling & can barely move. I don’t trust the vets anymore. Don’t want to put him down, but when does it end.

    • Maria

      Hello Stacey, I am so sorry to hear about your kitty. Did you try to find a Holistic Vet? Regular Vets only use nasty medicines which have tons of side effects.

  • my cat has been diagnosed with feline asthma was started on prednisolone, but still having attacks so vet put her on dexamethasone starting at 4mg now at 0.4mg and starting to get worse again, mainly in spring and fall unless over doing it playing, she’s about 7 or 8 lb and is 6 years old still loves to play, she’s a junglebob ( jungle cat and pixiebob) i also have a serval and a manx, manx is the old lady 9 years and serval ( ziva) is the middle child 3 years old, the junglebob and serval love to play chasing each other all over the house sometimes ginger( junglebob) gets to excited and starts coughing the serval seems to since something wrong and will stop playing until ginger starts again, my question is there something better or when i was giving the 4mg i didn’t have to give all the time, like 1 pill for 3 days then she might not have another attack for a month or 2 on the lower dose a lot more, she’s real good at taking pills i just open her mouth pop one in and down it go’s but she has a touchy stomach, to start with i was giving zyrtec ( i know make sure no aspirin) is there anything holistic ? that won’t hurt her stomach so bad? i’m trying to change everyone’s food to raw or partly anyway, the serval likes raw whole prey chicken ground up ginger will eat some of it but not totally she what’s friskies can as well, the raw helps keeping her weight down you know pills hungry all the time she’ll find something to eat if she has to open cabinets or the refrigerator! smart cat, thank you in advance.

  • MickMack

    My 16 year old cat had terrible diarrhea and blood in his stool. He was losing a lot of weight. It was awful. I thought he was dying on me. My vet prescribed Pednisolone thinking he might have some kind of of inflammatory bowl condition. It worked like magic and probably saved his life, but fist we had to find the right dosage .

    5mg a day was too much and he was having bad side effects, extreme lethargy, he stopped eating,and drinking and his diarrhea actually got worse. Half a pill 2.5mg ever other day was not enough his stool was normal the first day then back to diarrhea the second. Half a pill 2.5 mg a day seems to be the formula that works for him. He tolerates it well,and his stool remains normal. Mischief is much more active and healthy now,and is actually gaining weight. I am very pleased. Like I said I think it saved his life. Also the drug is very inexpensive $10 bucks a month

  • Christine

    What about steroids and eosinophilic granuloma and herpes. A mistake I see a lot in the veterinary field!!!!

  • LorinThePhotographer

    my cat with iBD is currently taking Budesonide. In combination with probiotics with every meal, it has a major favorable effect on her IBD.

    However, she know acts crazy. She paces aimlessly for hours, is restless and will stare at shadows. Her crazy behavior started when she had been on the drug for over a month.

    I took her off the Budesonide for a week and a half and ALL of her behavioral issues disppeared. Frankly, I don’t know what to do.

    Have a cat with untreated IBD or a cat who is out of her head.

    Please help

    • zenzete

      Try CBD. Check articles that describe CBD used to control IBD for cats.

      • LorinThePhotographer

        Unfortunately, on top of the IBD my precious little cat, Peanut had a brain tumor that was very aggressive. Peanut crossed the rainbow bridge in January

  • Trema Jennings

    My 5 yr old calico, pickles , had the depro medro injection Tuesday afternoon and has began to exhibit problems with her vision. The steroid will not be long term but I’m very concerned. Is this going to progress and become permanent damage