Tagged with " tumors"

Tissue and Fluid Samples: Why Are They Useful in Diagnosing Diseases?

Dec 13, 2012 by     No Comments    Posted under: Tips & Advice

Sampling of tissue and subsequent microscopic evaluation of tissue is described as collecting and interpreting a biopsy.  The preparation and evaluation of tissue is performed by a board certified pathologist.  Biopsies are used to evaluate masses and tumors, either inside the body, mouth or ears or on the external surface of the body (dermal or mammary tumors).  Biopsy samples can also be collected from tissue that is red or hairless or ulcerated as a means of differentiating cancer (neoplasia) from inflammatory, traumatized or infected tissue.

Analysis of fluid or a tissue sample is a diagnostic tool used in conjunction with blood and urine tests and imaging (radiographs, ultrasound, CT Scan or MRI) to narrow down a list of potential diseases in a cat.  Microscopic analysis of cells in fluid is referred to as cytology. Microscopic analysis of tissue (biopsy) is referred to as histopathology.  Samples of fluid are “aspirated” with a needle and tissue can be sampled with a small needle and syringe or by an incision that allows tissue to be collected. Fine needle samples of tissue can be collected with direct visualization if accessible to the eye or via one of the imaging systems mentioned above. When a tumor is removed, the entire mass can be submitted to the pathologist to ensure that all tumor cells were removed.  This is referred to as “checking margins” or making sure that “clean margins” are achieved , i.e. all of the cancer was removed.

Fluid samples are collected via a needle and syringe and often used to differentiate causes of abnormal free fluid accumulation in either the chest or abdomen of a cat.  Protein levels, bacterial isolation and microscopic evaluation of cell types are the usual tests done on fluid.  Some types of cancer will “shed” (exfoliate) cells into fluid and the exact cancer can be identified by microscopic evaluation of those cells. Lymphoma, the most common cancer in cats, usually exfoliates in the chest fluid if there is a lymphoma tumor in front of the heart. Feline Infectious Peritonitis (FIP) is a fatal viral (corona virus) disease that can cause abnormal fluid to accumulate in the chest or abdomen or both. FIP fluid has a characteristic yellow color, often contains a white blood cell type called macrophages and has high protein levels.  Congestive heart failure or non-exfoliating cancers like adenocarcinoma, will cause a clear watery fluid to collect in either the abdomen or chest that is free of cells.  Bacterial infection in the chest or abdomen (peritonitis) contains high levels of white blood cells (neutrophils or pus) called neutrophils and the causative bacteria can often be directly visualized inside the neutrophils or macrophages or may be grown on an agar plate (cultured) from the pus. Fluid extracted from around the brain or spinal cord  (cerebrospinal fluid) can be evaluated for inflammatory or cancer cells.

 

Dr Elyse Kent

Dr. Elyse Kent graduated from Michigan State University College of Veterinary Medicine in 1980 and completed an Internship at West Los Angeles Veterinary Medical Group in 1981.

In her early years in practice, Dr. Kent began to see a need for a separate medical facility just for cats, where fear and stress would be reduced for feline patients. In 1985, in a former home in Santa Monica, Dr. Kent opened the only exclusively feline veterinary clinic in Los Angeles, Westside Hospital for Cats (WHFC). Along with other forward-thinking feline practitioners from across North America, Dr. Kent founded the Academy of Feline Medicine in 1991. Through the efforts of these practitioners, feline medicine and surgery became a certifiable species specialty through the American Board of Veterinary Practitioners (ABVP). Dr. Kent became board certified in Feline Practice in the first group to sit for the Feline exam in 1995. She certified for an additional ten (10) years in 2005. There are now 78 feline specialists in the world. Dr. Kent served as the Feline Regent and Officer on the Council of Regents for 9 years. She is currently the immediate Past President of the ABVP, which certifies all species specialists. She also heads up a task force joining certain efforts of the ABVP with The American Animal Hospital Association (AAHA). She currently serves as a Director on the Executive Board of The American Association of Feline Practitioners.

The present day WHFC facility opened in 2000. It was the fulfillment of a vision for a spacious, delightful, state of the art, full service cat medical center that Dr. Kent had dreamed of and planned for over many years.

Westside Hospital for Cats
2317 Cotner Ave.
Los Angeles, CA 90064

Phone: 310-479-2428

Website: http://www.westsidehospitalforcats.com/
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The Diet That Suddenly Works

Dec 5, 2012 by     4 Comments    Posted under: Tips & Advice

My last blog was about dieting, but a more serious concern is the diet that suddenly starts producing results without having changed your cat’s dietary routine. Diets don’t suddenly start working on their own and you cannot wish those pounds away (or we all might be “svelte”). Basically we are talking about what we call “unexplained weight loss”.

Unexplained weight loss is exactly that. Weight loss without a good (or known) cause. The list of causes of unexplained weight loss is fairly long, however, we can usually narrow it down with a little detective work.

Cats, by nature, are stoic and they will not tell you that they are sick until they have to, so you need to be a detective at home as well. Very often the only sign of illness is weight loss. Your cat will try to tell you that everything is fine, but the scale will tell you otherwise.

Being a veterinary detective, we start with the obvious- diet. Have you changed how and what you are feeding your cat? If so, did this change result in fewer calories fed?

Is your cat choosing to eat less on his/her own? A decreased appetite is not specific to any particular disease, but is important information. Is your cat having difficulty eating? This could indicate and underlying dental problem (although most cats will continue to eat normally in the face of advanced dental disease).

Is your cat having intestinal upset (vomiting and/or diarrhea)? This will interfere with proper digestion of food.

Is your cat drinking and urinating more than usual? This could indicate (most commonly) diabetes or an underlying kidney infection.

Is your cat eating more and/or stealing food, yet losing weight? This can be consistent with an overactive thyroid gland or diabetes.

Is your cat on a regular deworming program? Has your cat had a recent fecal test? Parasites can cause weight loss, however, unless there is an overwhelming infection, they are unlikely to cause a drastic weight loss.

These observations are very important and should be shared with your veterinarian. Your veterinarian will need to perform a comprehensive examination on your feline friend. Very often a comprehensive examination along with a detailed history will help narrow the list of suspected diseases help develop a plan to uncover the problem.

In most cases an internal organ screen (blood and urine test) will be necessary. These screening tests give your veterinarian a lot of information – almost like an internal examination.

In some cases radiographs (x-rays) are needed. One of the causes of unexplained weight loss in seemingly healthy cats includes tumors in the chest. The chest is one area that cannot be palpated (or felt) during the examination because it is protected by the rib cage. Chest tumors can grow to a substantial size before causing obvious outward symptoms. An x-ray is necessary to check for chest tumors.

Once the screening test results are in hand, your veterinarian can either start treatment or discuss what additional testing (if any) is necessary. In most cases, if you have screened the blood, urine and stool and have normal x-rays and have still not found the cause of the weight loss, the next step is an abdominal ultrasound.

Ultrasound is a safe and painless way to evaluate internal organs in more detail. While x-rays show us the shape and position of the internal organs, an ultrasound can give us details of the internal parts of the organs. In cases of unexplained weight loss, we are especially concerned about the intestinal tract (one area where blood tests can’t accurately evaluate). The ultrasound can detect changes in the intestines and other organs and help pinpoint problems. While ultrasound will not always give you an exact diagnosis (a biopsy may be needed for this), it will provide a great deal of information and can help direct treatment, provide a prognosis (an idea of what to expect in the future) and other options to obtain a specific diagnosis.

Sometimes it is hard for cat owners to decide how far to go with testing. If you are unsure if you want to pursue an ultrasound and/or biopsy you need to discuss this with your veterinarian. Ultimately, the decision is yours. Our role as veterinarians is to help you make educated decisions about health care for your cats. Make a list of your questions and your concerns to review in your discussion. The most common question I get is “what will we do differently based on the results?” It isn’t possible to discuss treatments for every possible outcome of the testing, but it’s important to know that the results will be helpful.

So please watch your cat’s weight and be a veterinary detective at home. If your cat experiences unexplained weight loss, gather information and make an appointment with your veterinarian. It is much better for you and your cat if we can detect and treat a disease earlier than if we wait for your cat to show signs of illness. Unsure if your cat’s weight has changed? Most bathroom scales are not accurate enough to detect small changes in weight for cats. Either purchase an infant scale to use at home or call your veterinarian to see if you can bring your cat in to be weighed.

Dr Diana Lafer

Dr. Diana Lafer founded Cats Limited in 1995. She earned her bachelor’s degree in biology from Wesleyan University and her veterinary degree from Cornell University. Dr. Lafer has a cat (Sparky), and a dog (Lucy). She enjoys spending time with her daughters, horseback riding, skiing, hiking, participating in triathlons, and volunteering for the Lakeville Pony Club.

Cats Limited Hospital
1260 New Britain Avenue
West Hartford, CT 06110

Phone: (860) 561-9885
Email: cats@catslimited.com

Website: http://www.catslimited.com/
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